The Alpha-Stim® AID and Alpha-Stim M devices can help your patients reduce pain, feel better, and live better, quickly and safely.



The Alpha-Stim® AID and Alpha-Stim M devices can help your patients reduce pain, feel better, and live better, quickly and safely.


Treating Pain Effectively
Treating Mood Conditions
Research at a Glance
Online Product Brochures
History Of The Waveform
All Alpha Stim Research

Call or email for practitioner volume discount pricing at 1-800-FOR-PAIN (in USA), + (940) 328-0788 (outside USA), or info@epii.com

The best solution for your patients

We know you want what’s best for the people you treat – . You want options that provide the best outcomes with the fewest side effects and require the least amount of time and discomfort to your patient. And of course, you are looking out for their pocketbooks as well.

The FDA-cleared Alpha-Stim Cranial Electrotherapy Stimulation (CES) device and Microcurrent Electrical Therapy (MET) devices have helped hundreds of thousands of people achieve remarkable results. Surveys of Alpha-Stim users show overwhelming evidence of the effectiveness of the Alpha-Stim MET and CES device for treating chronic and acute pain, as well as anxiety, depression, and insomnia.

Used appropriately, the Alpha-Stim M MET and CES device and AID CES device may provide significant symptom improvements for many of your patients:

  • Patients suffering from pain, anxiety, or insomnia can enjoy noticeable relief after just one treatment
  • Depression patients typically get significant symptom relief after three weeks of daily treatments

Since 1981, Alpha-Stim has helped hundreds of thousands of people achieve remarkable results. Surveys of Alpha-Stim electrotherapy device users show overwhelming evidence of the effectiveness of the Alpha-Stim device, shown below:

% Reporting Significant Improvement (>25%)*


*Patient self-reports after using Alpha-Stim technology for at least 3 weeks.
Read the full survey report

Alpha-Stim is supported by over 100 completed independent research studies and published reports that utilize some of the most rigorous, controlled clinical study methods. Again and again, Alpha-Stim has proven to quickly and safely provide relief from pain, anxiety, depression, and insomnia.

Alpha-Stim patented waveform

Alpha-Stim waveform

How it works and what it does

The Alpha-Stim electrotherapy device works by transmitting a unique, patented electrical waveform to modulate the cells’ signals to return to baseline, normal functioning. The highly refined and rigorously tested waveform in our electrotherapy device uses microcurrents (millionths of an ampere), which are:

  • Transmitted into the brain in a precise configuration via earclip electrodes for the AID device (which treats anxiety, depression, and insomnia)
  • Also delivered via electrodes placed on the body at the pain site for the M device (to treat pain)

The results – significant reductions in pain, anxiety, depression, or insomnia – are instant and ongoing.


Alpha-Stim® M is an effective treatment with broad applications for a variety of syndromes involving pain. It also helps with the management of anxiety, insomnia and depression, or with the short-term relief of symptoms associated with these indications. In many cases, it is the sole therapeutic method required.

Effective results in pain management have been achieved during and/or subsequent to stimulation over affected body parts, adjacent areas, and areas distant from those in pain.

As with any therapeutic intervention, not all people will respond to the Alpha-Stim® M. The degree of efficacy will vary with the nature of the problem being treated, the overall health of the person, and the method of treatment. As much as a one-month initial trial may be required to see significant reductions in symptoms.

Alpha-Stim AID

Quickly and safely help patients get relief from anxiety, insomnia, and depression

Alpha-Stim M

Quickly and safely deliver sustainable pain relief along with relief from anxiety, insomnia, and depression

How to use Alpha-Stim

These videos offer step-by-step instructions on how to use the Alpha-Stim devices to relieve anxiety, insomnia, depression and pain. These devices can easily be used by the patients as well, saving them valuable time and money.

See How to Apply Alpha-Stim AID For Your Patients

See How to Apply Alpha-Stim M For Your Patients

It takes about 20 minutes to use in a patient’s home, and most Alpha-Stim users notice an immediate reduction in anxiety and an increased feeling of wellbeing from their first treatment.

Better yet, there’s no way to develop a “tolerance” for CES, so there’s never a need to increase dosages. Each treatment builds on the progress of the last. And once you’ve gotten your patients’ condition(s) under control, you can have them decrease use of the MET or CES device. Alpha-Stim is that powerful!

If you are a licensed healthcare practitioner and would like to attend a CES and MET education webinar with Jeff Marksberry, MD, Chief Science & Clinical Officer, please click here.

Adverse effects

Adverse effects are usually mild and self-limiting. According to data collected from 144 controlled studies, open clinical trials, uncontrolled conditions, and by a physician survey, side effects can include:

  • Dizziness (0.07%)
  • Skin irritation/ electrode burns ( 0.07%)
  • Headaches (0.10%)

Prolonged CES treatment at currents higher than necessary may cause dizziness or nausea that can last for hours to days. Treatment immediately prior to going to sleep may cause difficulty sleeping. Paradoxical reactions such as increased anxiety and sleep disturbances may occur but are rare.


Alpha-Stim may affect the operation of implanted demand type cardiac pacemakers and implanted defibrillators.

Do not stimulate directly on the eyes or press the probes over the carotid sinus (on the neck near the larynx).


Insurance coverage varies by policy. Durable medical equipment coverage is often required to obtain some level of reimbursement for Alpha-Stim devices.

EPI does not bill private carriers but will help by providing a paid invoice and a sample Statement of Medical Necessity for you to complete. Your patients may also use a flex spending account or HSA to purchase an Alpha-Stim.

A cost-effective solution

Alpha-Stim users can save thousands of dollars over a five-year period, compared to drugs and other treatment options for pain, anxiety, depression, and insomnia. There’s no safer, better value available.

Product Brochures

View or download the PDF brochures for the Alpha-Stim AID and Alpha-Stim M devices (multilingual options available)

View All


  1. Feusner JD, Madsen S, Moody T, et al. Effects of Cranial Electrotherapy Stimulation on resting state brain activity. Brain and Behavior. 2012;1-10.
  2. Taylor AG, Anderson JG, Riedel SL, et al. A randomized, controlled double-blind pilot study of the effects of Cranial Electrotherapy Stimulation on activity in brain pain processing regions in individuals with fibromyalgia. Explore. 2013; 9(1):32-40.
  3. Kennerly R. Changes in quantitative EEG and low resolution tomography following Cranial Electrotherapy Stimulation. PhD Dissertation, the University of North Texas. 2006; 529 pp., 81 tables, 233 figures, 171 references.
  4. Chen Y, Yu L, Zhang J, et al. Results of Cranial Electrotherapy Stimulation to children with mixed anxiety and depressive disorder. Shanghai Archives of Psychiatry. 2007; 19(4):203-05.
  5. Lande RG, Gragnani C. Efficacy of Cranial Electrotherapy Stimulation for the treatment of insomnia: A randomized pilot study. Complementary Therapies in Medicine. 2013; 21(1):8-13.
  6. Cork RC, Wood P, Ming N, et al. The effect of Cranial Electrotherapy Stimulation (CES) on pain associated with fibromyalgia. The Internet Journal of Anesthesiology. 2004; 8(2).
  7. Rintala DH, Tan G, Willson P, et al. Feasibility of using Cranial Electrotherapy Stimulation for pain in persons with parkinson’s disease. Parkinson’s Disease. 2010; 8 pages.
  8. Barclay TH, Barclay RD. A clinical trial of Cranial Electrotherapy Stimulation for anxiety and comorbid depression. Journal of Affective Disorders. 2014; 164:171-77.
  9. Mellen RR, Mackey W. Reducing sheriff’s officer’s symptoms of depression using Cranial Electrotherapy Stimulation (CES): A control experimental study. The Correctional Psychologist. 2009; 41(1):9-15.
  10. Winick RL. Cranial Electrotherapy Stimulation (CES): A safe and effective low cost means of anxiety control in a dental practice. General Dentistry. 1999; 47(1):50-55.
  11. Kolesos On, Osionwo Ho, Akkhigbe. The role of relaxation therapy and Cranial Electrotherapy Stimulation in the management of dental anxiety in Nigeria. ISOR Journal of Dental and Medical Sciences. 2013; 10(4):51-57.
  12. www.drugpriceinfo.com