Research at a glance

Safety, impressive results, and long-term effectiveness

Physician and patient surveys that show 90% of the people who use Alpha-Stim® CES and MET devices get significant relief when using it as a form of pain, anxiety, depression, or insomnia treatment. This is supported by over 100 completed independent research studies and published reports, many of which were randomly controlled trials to ensure rigorous testing and clinically validated results on the medical devices. That’s why over 200 Department of Defense (DOD) practitioners and over 92 Veterans Administration (VA) hospitals use Alpha-Stim with military personnel for acute, chronic, and post-traumatic pain, anxiety, depression, and insomnia treatment.

Proven to significantly reduce pain, anxiety, depression, and insomnia

Reduced pain

In a study of severe pain patients, Alpha-Stim significantly reduced pain by an average of 71% after only 5 treatments.1

In a post-traumatic pain study, 56% of patients at 3 months and 85% at 6 months were somewhat or very satisfied with the device.2

Chronic pain patients using Alpha-Stim reported significantly improved functionality than the usual care and sham groups.3

read more pain studies

Reduced anxiety

Eighty-three percent (83%) of the active Alpha-Stim CES group reported a decrease in anxiety of ≥ 50% on the HAM-A from baseline to endpoint of study4

In a study of preoperative anxiety, Alpha-Stim recipients reported significantly less anxiety after one 20 minute application5

Read more anxiety studies

Reduced depression

Alpha-Stim CES recipients reported an 82% decrease in depression after 5 weeks of treatment4

After 6 weeks of treatment, Alpha-Stim users experienced 42.8% improvement8

Read more depression studies

Reduced insomnia

Increased Sleep Time: Alpha-Stim CES recipients demonstrated an average increase of 43 total minutes of sleep time after only 5 treatments*6

Reduced Sleep Disturbances: Alpha-Stim CES reduced sleep disturbances with patients, completing this 8-week study with scores below the range of insomnia7

Read more insomnia studies


Alpha-Stim has proven its safety in 95 research studies, published reports and ongoing research, physician and patient surveys. Scores of professionals who have used Alpha-Stim technology for pain, anxiety, depression, or insomina treatment have remarked on the unsurpassed safety and quality of the devices.

In over 30 years of studies involving 8,800 people, only minor side effects have been reported. The two most common side effects were headaches (0.10%) and skin irritation at the electrode sites (0.07%, only seen in light-skinned people).

Patients who reported a positive response,
according to: 2011 WebMD Drug Surveys,
2011 Alpha-Stim Service Member Survey (N=152),
and 2011 Alpha-Stim Civilian Patient Survey (N=1,745).9,10


  1. Holubec JT. Cumulative response from Cranial Electrotherapy Stimulation (CES) for chronic pain. Practical Pain Management. 2009; 9(9):80-83.
  2. Tan G, Rintala D, Jensen MP, et al. Efficacy of Cranial Electrotherapy Stimulation for neuropathic pain following spinal cord injury: a multi-site randomized controlled trial with a secondary 6-month open-label phase. Journal of Spinal Cord Medicine. 2011; 34(3):285-296.
  3. Taylor AG, Anderson JG, Riedel SL, et al. Cranial Electrotherapy Stimulation improves symptoms and functional status in individuals with fibromyalgia. Pain Management Nursing. 2013 Dec; 14(4):327-335.
  4. Barclay TH, Barclay RD. A clinical Trial of cranial electrotherapy stimulation for anxiety and comorbid depression. Journal of Affective Disorders. 2014; 164:171-177. Presented at the American Psychological Association National Conference, Honolulu, July 2013.
  5. Lee S-H, Kim W-Y, Lee C-H, et al. Effects of cranial electrotherapy stimulation on preoperative anxiety, pain and endocrine response. Journal of International Medical Research. 2013; 41(6) 1788–1795.
  6. Lande, R. Gregory and Gragnani, Cynthia. Efficacy of cranial electric stimulation for the treatment of insomnia: A randomized pilot study. Complementary Therapies in Medicine. 2013; 21(1):8-13.
  7. Taylor AG, Anderson JG, Riedel S L., Lewis, et al. Cranial electrical stimulation improves symptoms and functional status in individuals with fibromyalgia. Pain Management Nursing. 2013; Dec;14(4):327-35.
  8. Bystritsky A, Kerwin  L, Feusner J. A pilot study of cranial electrotherapy stimulation for generalized anxiety disorder. Journal of Clinical Psychiatry. 2008; 69:412-417. Presented at the American Psychiatric Association meeting, San Francisco, 2009.
  9. Accessed online October 28, 2011 at Pharmaceutical survey data.
  10. Alpha-Stim Military Service Member and Civilian Data. 2011. Conducted by Larry Price, PhD, Associate Dean of Research and Professor of Psychometrics and Statistics, Texas State University.